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Old 12-29-2008, 04:07 AM
qazxsw123 qazxsw123 is offline
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Default What is BMP-2?

Human bone morphogenetic protein-2 (BMP-2) is involved in the development of many organs and tissues as well as in the estab-lishment of the basic embryonic body plan. This implies its potential use in the regeneration of many types of tissues following injuries and dis-eases. It has the unique capacity of inducing bone regeneration and ectopic bone formation in adult vertebrates. In fact, clinical trials performed recently have shown that, when delivered properly, recombinant BMP-2 is effective and safe alterna-tives to autologous bone grafting. Further therapeutic applications, including its application for osteointegration of metallic implants, tendon and ligaments reunion with bones, cartilage repair and even in non-skeletal diseases, are foreseen.

  Biologically active BMP-2 is a homodimer, linked by a single disulfide bond. The monomers have three intrachain disulfide bridges, forming a so-called cystine knot. In vivo, the monomer is synthesized as a large precursor, which after dimerization, is prote-olytically cleaved releasing the smaller C-terminal fragment forming the mature dimer

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Last edited by qazxsw123; 12-29-2008 at 04:15 AM..
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